cenobamate will minimize the level or effect of fentanyl transdermal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Improve dose of CYP3A4 substrate, as essential, when coadministered with cenobamate.fentanyl transdermal and imipramine the two enhance sedation. Avoid or Use Alternate Drug. Restrict